1008. ECHINOPS WAKHANICUS: Compositae

Dmd057018 1008..1015

The glycogen synthase kinase-3 inhibitor LY2090314 specifically impaired CYP2B6 activity during in vitro evaluation of cytochrome P450 (P450) enzyme induction in human hepatocytes. CYP2B6 catalytic activity was significantly decreased following 3-day incubation with 0.1–10 mM LY2090314, on average by 64.3%6 5.0% at 10 mM. These levels of LY2090314 exposure were not cytotoxic to hepatocytes and ...

Npgrj_nbt_1113 1008..1012

Cationic antimicrobial peptides are able to kill a broad variety of Gram-negative and Gram positive bacteria and thus are good candidates for a new generation of antibiotics to treat multidrug-resistant bacteria. Here we describe a highthroughput method to screen large numbers of peptides for improved antimicrobial activity. The method relies on peptide synthesis on a cellulose support and a Ps...

Jgp_201711845 985..1008

985 Introduction Despite the ability of ion channel biophysics to provide insightful inferences regarding structural features of a given ion channel, those invested in biophysical approaches eagerly await each advance in structural information, hoping to gain clarity or validation regarding functional questions or to identify new directions to better probe and understand function. One such chan...

Wood Anatomy of Vernonieae (Compositae)

Systematics of Isocarpha (Compositae: Eupatorieae)

Isocarpha comprises five species ranging from southern Texas and the Bahamas to northern Peru and northeastern Brazil. The genus belongs in Eupatorieae rather than Heliantheae, but structure of the head of Isocarpha with its elongate, chaffy receptacle is anomalous within Eupatorieae. An hypothesis is presented suggesting the evolutionary derivation of this type of head through formation of flo...